Christan Zaccagnino awoke at Xishan Hospital near Beijing with a roaring headache.The
24-year-old Port Chester woman had just endured two hours of spinal
cord surgery. Doctors transplanted cells above and below the spot in
her spinal cord that was injured 14 years earlier in a diving accident.
They hoped to restore movement and feeling to her paralyzed body.
Zaccagnino
is among hundreds of people with spinal cord injuries and other
debilitating afflictions who have placed their faith in Dr. Hongyun
Huang, a Chinese neurosurgeon who has transplanted fetal brain tissue
into the lesions of more than 400 such patients from across the world.
The
controversial surgery has no documented success rate, and a recent
American medical journal study advises doctors to warn patients against
it.
But Zaccagnino ignored the skeptics and went to China in
April. Five months after the surgery, she said she is showing some
promising results in her strength and posture.
"These little
things that I was never able to do -it's not even six months and I'm
already seeing changes," Zaccagnino said recently. "I'm extremely happy
with my progress. I couldn't ask for anything more."
Zaccagnino
left for Beijing on April 18 with her father and her boyfriend, Army
1st Lt. Boyd Melson, after raising the $30,000 needed for the surgery
through fundraisers and T-shirt sales.
Though the shabby
condition of the Chinese hospital was startling at first, Zaccagnino
said, she soon felt at home in her austere quarters - a small room with
four concrete walls, two beds and a DVD player.
She was
surrounded by patients from Greece, Italy, Romania, France and other
countries, all awaiting Huang's surgery. The families prayed together
as their loved ones were wheeled into the operating room.
The day
before her own surgery, Zaccagnino began to have second thoughts as
nurses shaved off the back of her lustrous hair. She watched the blond
strands - "the only thing not affected by the accident" - fall from the
back of her neck and panicked.
She looked up at Melson, who said: "I believe in you. We all believe in you."
"Those
words kind of resonated," Zaccagnino said. "I thought: 'I have so much
support behind me. I'm so blessed. I can do this.' "
The next
day, she went into the operating room as friends and family back home
attended a prayer meeting at her parents' house in Port Chester.
Zaccagnino calls the decision to go ahead with the surgery "one of the
hardest things I've ever done."
Huang normally uses cells from
aborted human fetuses to implant into the brains and spines of
patients, but Zaccagnino said because of her religious objections, he
used stem cells derived from her own arm and leg for her operation.
Zaccagnino
was 10 when she dived into her parents' above-ground swimming pool, hit
her head on the bottom, and broke two of her Vertebrae and injured her
spinal cord. She was paralyzed from the neck down.
At the
hospital, her parents were told she would never walk again, and, at
best, might recover limited feeling in her upper body. But after
intense Physical Therapy and training, she was able to move her arms,
walk with leg braces and a walker, and pedal a stationary bike with
assistance.
Fourteen years after her injury, Zaccagnino, a
student at Iona College, hoped the surgery in China would help her
reach her ultimate goal of standing and walking without braces.
American
doctors expressed skepticism about Huang's surgery in a 2006 article
"Neurorehabilitation and Neural Repair." The doctors observed seven
spinal cord injury patients who underwent Huang's surgery and said no
significant improvements were found. Five of the seven patients also
had complications like meningitis.
"The procedures observed did
not attempt to meet international standards for either a safety or
efficacy trial," the article said. "In the absence of a valid clinical
trials protocol, physicians should not recommend this procedure to
patients."
Attempts to reach Huang via e-mail and through a medical assistant were unsuccessful.
Despite
his detractors, Huang entices patients to his surgery with his optimism
and their sense of frustration with the slow pace of American medicine.
Chris
Olson of Madison, S.D., had the surgery in September 2003, two years
after he was paralyzed from the shoulders down in a car accident. He
was the third known American to go to Huang.
"I wasn't delusional
to think that I would be restored to what I was before, but I was
hoping to gain a little movement in my hand," he said.
Olson, 29,
said he did not get back the movement he had hoped for, but he found
many small improvements encouraging. After the surgery, he could feel
sensations lower on his chest, arms and hands, and some movement
returned to his wrist muscles. He did not achieve his main goal of new
movement in his fingers, but that did not sour him on his experience in
China.
"For me, the hope was worth it and trying to get something instead of not trying was worth it to me," Olson said.
Zaccagnino
also said she has no regrets about the surgery, and hopes to act as a
liaison for American families considering the trip to Beijing. She said
she would recommend the surgery to others with spinal cord injuries.
Immediately
after the operation, Zaccagnino said, she felt her calves and the back
of her legs for the first time since the accident, and three days later
she could clench her thighs. The surgery has helped her feel more in
control of her muscles and body. She sits straighter and can regulate
her body temperature more efficiently.
"I feel like the things that I see, it's hard to show the average person," Zaccagnino said.
Her
personal trainer, Lindsay Huisman, who specializes in spinal cord
injuries, said after the surgery Zaccagnino could push outward with her
feet for the first time. Her legs, muscles and feet are more active,
and she has occasional muscle spasms in the center of her stomach and
obliques.
"The changes that I've seen are consistent on a
timeline from when she had her surgery," said Huisman, who trains
Zaccagnino at Push to Walk, a Rehabilitation and recovery facility in
New Jersey. "I'm not a medical doctor and I can't say that it's the
result of a certain type of cell. I can't say because I don't know."
Meanwhile, Zaccagnino and Melson are turning their attention toward other, additional treatments.
"We
definitely already have little tricks up our sleeves," Zaccagnino said.
"We try to keep it to ourselves, but we're looking into things."